11+ hour, 45+ min ago  (190+ words) Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) immune-mediated necrotizing myopathy (IMNM) is a subtype of autoimmune necrotizing myopathy that presents with progressive proximal weakness and persistent creatine kinase (CK) elevation, which may continue despite statin discontinuation. Its relationship with hematologic malignancy…...

1+ hour, 25+ min ago  (195+ words) Cerebral amyloid angiopathy (CAA) is a highly prevalent condition that often poses diagnostic and therapeutic challenges, especially in people with comorbid mild cognitive impairment (MCI). Open Evidence (OE; Miami, Florida, US), a leading free medical knowledge copilot, reports it has supported…...

11+ hour, 45+ min ago  (346+ words) Introduction Point-of-care ultrasound (POCUS) has seen rapid growth in recent years and has become a key part of everyday diagnostic assessments in clinical practice. With the growing concern over the frequency of unnecessary testing in hospitalized patients, often leading to…...

11+ hour, 45+ min ago  (464+ words) Background End-stage renal disease (ESRD) is associated with substantial cardiovascular morbidity, partly because advanced renal failure is accompanied by metabolic and lipid disturbances. The LDLR gene plays a key role in cholesterol homeostasis, and rs688 may influence low-density lipoprotein (LDL) receptor function…...

11+ hour, 45+ min ago  (232+ words) Minimally invasive orthopaedic surgical techniques are widely used to reduce surgical trauma and enhance perioperative recovery while maintaining clinical effectiveness. This systematic review and meta-analysis evaluated the efficacy and safety of minimally invasive techniques compared with conventional open surgery across…...

1+ day, 11+ hour ago  (181+ words) Rayan Muawad " Yasser M. Almashari " Joana Mandoorah " Ziyad K. Alharbi " Wasan Alenezi " Rayan Almutairi " Mostafa Nagy Chronic pain affects approximately one-quarter of pediatric scoliosis patients but decreases over time. Younger age and absence of postoperative morphine infusion were associated with higher chronic…...

11+ hour, 45+ min ago  (241+ words) Community-based preventive health interventions have emerged as central strategies for improving population health and reducing preventable morbidity and mortality across diverse communities. These approaches extend beyond clinical care and incorporate behavioral, environmental, social, and structural components delivered within local settings....

1+ day, 11+ hour ago  (225+ words) Type IV paraesophageal hiatal hernias are rare but carry a significant risk of life-threatening complications, including gastric volvulus, incarceration, and the involvement of other intra-abdominal organs. Pancreatic herniation and associated pancreatitis are exceedingly uncommon. We report the case of a…...

1+ day, 11+ hour ago  (330+ words) Background and aim COVID-19 m RNA vaccines were granted Emergency Use Authorization by the United States FDA in December 2020. Serious adverse events following immunization (AEFI) with COVID-19 vaccines started to be seen by clinicians soon after the vaccines were available…...

22+ hour, 1+ min ago  (536+ words) Ninad Shinde " Vijaykumar G. Warad " Shravankumar Potkar " Shridhar Patil Introduction: Type 2 diabetes mellitus (T2 DM) is a growing global health concern. Emerging evidence suggests that vitamin D and calcium play an important role in glucose metabolism and insulin function. The present study aimed…...